2-Chloroethylamine hydrochloride → 4-(N,N-Dimethylcarbamimidoyl)benzoic acid hydrochloride

HRID 747786Notes

Reaction equation

HRID 747786 reaction equation
[CH3:1][N:2]([CH3:16])[C:3]([C:5]1[CH:15]=[CH:14][C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][CH:6]=1)=[NH:4].Cl.[Cl:18]CCN>Cl>[ClH:18].[CH3:1][N:2]([CH3:16])[C:3]([C:5]1[CH:15]=[CH:14][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)=[NH:4]

Participants

4

Reactant 2

HCID 97937372-Chloroethylamine hydrochlorideHCID 22631319ethyl 4-(N,N-dimethylamidino)benzoate

Product 1

HCID 534445094-(N,N-Dimethylcarbamimidoyl)benzoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Ethyl 4-(N,N-dimethylamidino)benzoate (compound of step 1 in Example 7) was heated under reflux in 6 N hydrochloric acid for 6 hours, and then the solvent was distilled off to obtain the title compound.

Workup

  1. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-011748c33dcb4f3bb3746db45c807910
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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