Potassium Carbonate → HCID 53999571, compound

HRID 747795Notes

Reaction equation

HRID 747795 reaction equation
[CH2:1]([C@@H:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:9]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:25]([C:27]1[CH:28]=[C:29]([OH:33])[CH:30]=[CH:31][CH:32]=1)#[N:26]>CN(C)C=O>[CH2:1]([C@@H:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:9][O:33][C:29]1[CH:30]=[CH:31][CH:32]=[C:27]([C:25]#[N:26])[CH:28]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 133943-CyanophenolHCID 68831229HCID 68831229, compound

Product 1

HCID 53999571HCID 53999571, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

8.52 g (31.6 mmol) of t-butyl N-[(1R)-1-benzyl-2-chloroethyl]carbamate, 12.1 g (87.5 mmol) of potassium carbonate and 5 g (41.9 mmol) of 3-cyanophenol were reacted in 120 ml of dimethylformamide as the solvent at 70° C. overnight. After the treatment in an ordinary manner followed by the silica gel column chromatography, the title compound was obtained.

Sources & evidence

ORD record
ord-7cfb785e21d1466cbe8c3a8ed7e234a0
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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