反应详情

1.74 g of 4-Chloromethyl-5-methyl-2-(4-(2-propyl)-phenyl)-oxazole and 3 g of sodium iodide in 150 ml of acetone are heated under reflux for 2 hours. After the reaction mixture has been cooled, 300 ml of methyl tert-butyl ether are added, the mixture is washed three times with saturated Na2S2O3 solution and dried over MgSO4 and the solvents are then removed under reduced pressure. This gives 2.64 g of 4-iodomethyl-5-methyl-2-(4-(2-propyl)-phenyl)-oxazole as a yellowish solid. C14H16INO (341.19), MS(ESI): 342 (M+H+).

1. temperatureunder reflux for 2 hours
2. temperatureAfter the reaction mixture has been cooled
3. washthe mixture is washed three times with saturated Na2S2O3 solution
4. dry with materialdried over MgSO4
5. customthe solvents are then removed under reduced pressure