Water → HCID 24699773, compound

HRID 748141Notes

Reaction equation

HRID 748141 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1.O>CN1CCCC1=O>[F:10][C:11]1[CH:12]=[CH:13][C:14]([N:17]2[CH2:22][CH2:21][N:20]([C:2]3[CH:7]=[C:6]([CH:5]=[CH:4][N:3]=3)[C:8]#[N:9])[CH2:19][CH2:18]2)=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 962WaterHCID 752601-(4-Fluorophenyl)piperazineHCID 5686382-Chloro-4-cyanopyridine

Product 1

HCID 24699773HCID 24699773, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
100 °C

Procedure

2-Chloro-4-cyanopyridine (0.40 g, 2.9 mmol) was dissolved in N-methylpyrrolidone (2.0 ml), and 1-(4-fluorophenyl)piperazine (1.0 g, 5.6 mmol) was added thereto. The reaction mixture was stirred at 100° C. for 10 hrs, combined with water to give precipitates, which were collected by filtration to give the titled compound (0.70 g, 86%).

Workup

  1. customto give
  2. customprecipitates
  3. filtrationwhich were collected by filtration

Sources & evidence

ORD record
ord-88c323b8d1bc45d094de2fdeb976f2ce
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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