反应详情

温度

80 °C

A mixture of 6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridinecarboxylic acid (350 mg, 1.2 mmol), WSC (471 mg, 2.4 mmol), HOBt (332 mg, 2.4 mmol) and DMF (10 ml) was stirred at 80° C. for 17 hrs. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with water and dried. The solvent was evaporated. The residue was subjected to a silica gel column chromatography, eluted with ethyl acetate-methanol (50:1, v/v) and recrystallized from tetrahydrofuran-hexane to give the titled compound (167 mg, 40%).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. customThe solvent was evaporated
5. washeluted with ethyl acetate-methanol (50:1
6. customv/v) and recrystallized from tetrahydrofuran-hexane