HCID 59750101, compound → HCID 59750357, compound

HRID 748443Notes

Reaction equation

HRID 748443 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:13]3[S:14][C:15]4[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=4[C:17](=[O:19])[N:18]=3)[CH:8]=2)[CH2:5][CH2:4][N:3]1[CH2:24][C:25]([O:27]C(C)(C)C)=[O:26]>FC(F)(F)C(O)=O>[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:13]3[S:14][C:15]4[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=4[C:17](=[O:19])[N:18]=3)[CH:8]=2)[CH2:5][CH2:4][N:3]1[CH2:24][C:25]([OH:27])=[O:26]

Participants

3

Reactant 1

HCID 59750101HCID 59750101, compound

Product 1

HCID 59750357HCID 59750357, compoundYield 82.2%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
0 °C

Procedure

tert-Butyl [2-oxo-3-[2-(4-oxo-4H-1,3-benzothiazin-2-yl)-4-pyridyl]-1-imidazolidinyl]acetate (0.31 g, 0.70 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at 0° C. for 2 hrs. The solvent was evaporated and the residue was recrystallized from diethyl ether-methanol to give the titled compound (0.22 g, 81%) as white crystals.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from diethyl ether-methanol

Sources & evidence

ORD record
ord-b5db8e7775c3420795c9d54e8798bd6b
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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