Trifluoroacetic acid → HCID 68458121, compound

HRID 748474Notes

Reaction equation

HRID 748474 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[CH:17]=[C:16]([CH:18]3[CH2:22][CH2:21][CH2:20][N:19]3C(OC(C)(C)C)=O)[CH:15]=[CH:14][N:13]=2)=[N:3]1.[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[NH:19]1[CH2:20][CH2:21][CH2:22][CH:18]1[C:16]1[CH:15]=[CH:14][N:13]=[C:12]([C:4]2[S:5][C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[C:2](=[O:1])[N:3]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59750423HCID 59750423, compound

Product 1

HCID 68458121HCID 68458121, compoundYield 85%

Procedure

tert-Butyl 2-[2-(4-oxo-4H-1,3-benzothiazin-2-yl)-4-pyridyl]-1-pyrrolidinecarboxylate (0.35 g, 0.85 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at room temperature for 3 hrs. The solvent was evaporated, and the residue was recrystallized from diisopropyl ether-methanol to give the titled compound (0.31 g, 85%) as white crystals.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from diisopropyl ether-methanol

Sources & evidence

ORD record
ord-1e0f688c337d480eae2733f4cd76ab1e
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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