1-Ethylpiperazine → HCID 822459, compound

HRID 748516Notes

Reaction equation

HRID 748516 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].[Cl:9][C:10]1[N:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1>>[Cl:9][C:10]1[N:15]=[CH:14][C:13]([S:16]([N:6]2[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]2)(=[O:18])=[O:17])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 791961-EthylpiperazineHCID 27927922-Chloro-5-pyridinesulfonyl chloride

Product 1

HCID 822459HCID 822459, compoundYield 83%

Procedure

The title compound was prepared as described for Example 25 using N-ethylpiperazine and 6-chloropyridine-3-sulfonyl chloride (described in: Naegeli, C. et al. Helv. Chim. Actal. 1938, 21, 1746-1750). Yield:83%: 1H NMR (CDCl3, 400 MHz) δ 8.75 (d, J=3 Hz, 1 H), 7.97 (dd, J=8, 3 Hz, 1 H), 7.50 (d, J=8 Hz, 1 H), 3.16-3.06 (m, 4 H), 2.60-2.46 (m, 4 H), 2.42 (q, J=7 Hz, 2 H), 1.04 (t, J=7 Hz, 3 H); 13C NMR (CDCl3, 100 MHz) δ 155.8, 148.9, 137.8, 131.3, 124.7, 51.9, 51.6, 46.0, 11.9; MS (ES) m/z 290 (M++1).

Sources & evidence

ORD record
ord-b337139620264f94965a23505f9babea
Source dataset
uspto-grants-2008_07
Patent number
US07399780B2

Reaction notes

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