Trifluoroacetic acid → HCID 59750924, compound

HRID 748706Notes

Reaction equation

HRID 748706 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([CH:18]([C:27]2[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=2[F:34])[CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])(=[O:17])=[O:16])=[CH:11][CH:10]=1>C(Cl)Cl>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([S:15]([CH:18]([C:27]2[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=2[F:34])[CH2:19][C:20]([OH:22])=[O:21])(=[O:17])=[O:16])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59750758HCID 59750758, compound

Product 1

HCID 59750924HCID 59750924, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At 0° C., trifluoroacetic acid (10 ml) was added to a methylene chloride (30 ml) solution of t-butyl 3-[(4-chlorophenyl)sulfonyl]-3-(2,5-difluorophenyl)propionate (3.10 g, 7.43 mmol). The resulting mixture was stirred at room temperature for 2 hours. To the residue obtained by concentrating the reaction mixture was added toluene and the resulting mixture was concentrated. The residue thus obtained was recrystallized from ethyl acetate-hexane, whereby the title compound (2.29 g, 85%) was obtained as colorless needle crystals.

Workup

  1. customTo the residue obtained
  2. concentrationby concentrating the reaction mixture
  3. additionwas added toluene
  4. concentrationthe resulting mixture was concentrated
  5. customThe residue thus obtained
  6. customwas recrystallized from ethyl acetate-hexane, whereby the title compound (2.29 g, 85%)
  7. customwas obtained as colorless needle crystals

Sources & evidence

ORD record
ord-e4b8b1ea05e84ba9b37113927c449fd4
Source dataset
uspto-grants-2008_07
Patent number
US07399775B2

Reaction notes

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