Dichloromethane → HCID 59750892, compound

HRID 748759Notes

Reaction equation

HRID 748759 reaction equation
ClCCl.[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([CH:14]([C:24]2[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=2[F:31])[CH2:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])(=[O:13])=[O:12])=[CH:7][CH:6]=1.FC(F)(F)C(O)=O>C(OCC)(=O)C>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]([S:11]([CH:14]([C:24]2[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=2[F:31])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])(=[O:13])=[O:12])=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59750864HCID 59750864, compound

Product 1

HCID 59750892HCID 59750892, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a dichloromethane solution (10 ml) of t-butyl 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)butyrate (1.25 g, 3.33 mmol) was added trifluoroacetic acid (5 ml). The resulting mixture was stirred at room temperature for 4 hours. The solid obtained by concentrating the reaction mixture was recrystallized from ethyl acetate, whereby the title compound (595 mg, 1.59 mmol, 48%) was obtained as colorless needle crystals.

Workup

  1. customThe solid obtained
  2. concentrationby concentrating the reaction mixture

Sources & evidence

ORD record
ord-433ff3dde4bd413cbfe5036d38a353f8
Source dataset
uspto-grants-2008_07
Patent number
US07399775B2

Reaction notes

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