Hydrochloric Acid → HCID 68519472, compound

HRID 748878Notes

Reaction equation

HRID 748878 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]([O:29][C:30]3[CH:35]=[CH:34][C:33]([O:36][CH2:37][CH2:38][N:39]4[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]4)=[CH:32][CH:31]=3)=[C:13]3[C:18](=[CH:19][CH:20]=2)[CH:17]=[C:16]([O:21][C:22](=[O:28])[O:23][CH2:24][CH:25]([CH3:27])[CH3:26])[CH:15]=[CH:14]3)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:45].CCOCC>ClCCl>[ClH:45].[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:12]([O:29][C:30]3[CH:31]=[CH:32][C:33]([O:36][CH2:37][CH2:38][N:39]4[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]4)=[CH:34][CH:35]=3)=[C:13]3[C:18](=[CH:19][CH:20]=2)[CH:17]=[C:16]([O:21][C:22](=[O:28])[O:23][CH2:24][CH:25]([CH3:26])[CH3:27])[CH:15]=[CH:14]3)=[CH:9][CH:10]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 59751427HCID 59751427, compound

Product 1

HCID 68519472HCID 68519472, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dissolve the compound of Example 9 (104 mg, 0.17 mmol) in dichloromethane (3 mL) and add 2M HCl in ether (400 μL, 0.8 mmol). Remove the solvent in vacuo to yield 81 mg of the title compound (73%): mass spectrum (ion spray): m/z=618.3 (M+H—HCl).

Workup

  1. customRemove the solvent in vacuo

Sources & evidence

ORD record
ord-f65b32ba038845c9bad8172e219782c5
Source dataset
uspto-grants-2008_07
Patent number
US07399867B2

Reaction notes

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