反应详情

温度

20 °C

A mixture of 4-benzyloxy-3-methoxy-6-nitrobenzonitrile (46 g, 162 mmol), sodium bicarbonate (95 g, 1.13 mol), water (750 ml), dichloromethane (550 ml) and tetrabutylammonium chloride (30 g, 108 mmol) was rapidly stirred at 20° C. and treated portionwise with sodium dithionite (66 g, 379 mmol) over 2 hours. The mixture was stirred for a further 1 hour then the phases separated. The aqueous phase was extracted with dichloromethane (2×200 ml) and the combined organic solution washed with water (300 ml) and dried over magnesium sulphate. The solution was concentrated to 250 ml and 4.0 N hydrochloric acid in 1,4-dioxane (150 ml, 0.6 mol) added. The reaction was then diluted with diethyl ether (1000 ml) and cooled on ice. The resulting solid was collected by suction filtration and washed with diethyl ether. The solid was stirred in methanol (1000 ml) and sodium bicarbonate solution (800 ml) added (pH 8) and the mixture stirred for 1 hour. The solid was collected by suction filtration, washed with water, methanol and dried in vacuo to yield 2-amino-4-(benzyloxy)-5-methoxybenzonitrile (34 g, 82% yield) as light brown solid:

1. stirringThe mixture was stirred for a further 1 hour
2. customthe phases separated
3. extractionThe aqueous phase was extracted with dichloromethane (2×200 ml)
4. washthe combined organic solution washed with water (300 ml)
5. dry with materialdried over magnesium sulphate
6. additionadded
7. temperaturecooled on ice
8. filtrationThe resulting solid was collected by suction filtration
9. washwashed with diethyl ether
10. stirringThe solid was stirred in methanol (1000 ml)
11. additionsodium bicarbonate solution (800 ml) added (pH 8)
12. stirringthe mixture stirred for 1 hour
13. filtrationThe solid was collected by suction filtration
14. washwashed with water, methanol
15. customdried in vacuo