2-Fluorophenol → 2-Chloro-6-fluorophenol

HRID 749260Notes

Reaction equation

HRID 749260 reaction equation
[Cl:1]Cl.[F:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10]>>[Cl:1][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([F:3])[C:5]=1[OH:10]

Participants

3

Reactant 2

HCID 97072-FluorophenolHCID 24526Chlorine3×

Product 1

HCID 27737102-Chloro-6-fluorophenol

Procedure

4 g (56 mmol) of chlorine is introduced at this temperature. Then 60.5 g (540 mmol) of 2-fluorophenol are dropped in the solution over about 2 hours, while at the same rate 42 g (590 mmol) more chlorine is Introduced. After that 4 g more chlorine are introduced to complete the chlorination.

Workup

  1. additionis Introduced

Sources & evidence

ORD record
ord-367a6d9629a04a91b3cfc3497a7bf7dc
Source dataset
uspto-grants-2008_07
Patent number
US07402603B2

Reaction notes

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