反应详情

To a solution of 3-((2-(5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)-1-methylcyclohexanol, 28b, in THF was added a few drops of 25% sodium methoxide at room temperature. The reaction mixture was stirred at room temperature for 5 min. The reaction mixture was diluted with ethyl acetate and brine. The organic phase was separated, dried (MgSO4), filtered and concentrated in vacuo. The product was purified by preparatory HPLC to afford two diastereomers.

1. customThe organic phase was separated
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe product was purified by preparatory HPLC
6. customto afford two diastereomers