Hydrochloric Acid → HCID 68979965, compound

HRID 749425Notes

Reaction equation

HRID 749425 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][C@H:10]([C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1)[CH2:11][CH2:12][N:13]1[CH2:16][CH:15]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:14]1)C)(C)(C)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[ClH:31].[F:29][C:26]1[CH:27]=[CH:28][C:23]([C@H:10]([CH2:11][CH2:12][N:13]2[CH2:14][CH:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[CH2:16]2)[CH2:9][NH:7][CH3:6])=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68978670HCID 68978670, compound

Product 1

HCID 68979965HCID 68979965, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl[(2S)-2-(4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl]-methylcarbamate (0.44 g, 1.04 mmol) was dissolved in a HCl-saturated solution of ethyl acetate. The mixture was stirred at room temperature for 1 h and then the solvent was removed by evaporation. There was obtained 450 mg of [(2S)-2-(4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl]methylamine dihydrochloride as a foam. 1H NMR (500 MHz, CD3OD): 2.0 (m, 1H), 2.2 (m, 1H), 2.7 (s, 3H), 3.0-5.0 (cm, 18H), 7.2 (t, 2H), 7.5 (t, 2H); LCMS: m/z 322 (M+1)+.

Workup

  1. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-3bf9524574af4e5092086e38987d0a40
Source dataset
uspto-grants-2008_07
Patent number
US07402581B2

Reaction notes

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