Hydrochloric Acid → HCID 69306516, compound

HRID 749489Notes

Reaction equation

HRID 749489 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:24])[CH:7]([C:19]([O:21]CC)=[O:20])[C:8](=[O:18])[N:9]2[C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[CH:4][C:3]=1[NH:25][C:26]1[C:31]([F:32])=[CH:30][C:29]([F:33])=[CH:28][C:27]=1[Cl:34].Cl>C(O)C>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:24])[CH:7]([C:19]([OH:21])=[O:20])[C:8](=[O:18])[N:9]2[C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[CH:4][C:3]=1[NH:25][C:26]1[C:31]([F:32])=[CH:30][C:29]([F:33])=[CH:28][C:27]=1[Cl:34]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69306485HCID 69306485, compound

Product 1

HCID 69306516HCID 69306516, compoundYield 62.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

12 mg (0.02 mmol) of ethyl 7-chloro-6-(2-chloro-4,6-difluorophenylamino)-4-oxo-1-pyridin-3-yl-1,4-dihydroquinolone-3-carboxylate were suspended in 6 ml of an ethanol/2 N sodium hydroxide solution mixture (1:1) and heated at 90° C. for 3 hours. After cooling to room temperature, the pH was adjusted to 2 with 2 N hydrochloric acid and the precipitate was filtered off with suction. 6 mg (53%) of the product were obtained.

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthe precipitate was filtered off with suction

Sources & evidence

ORD record
ord-8e42a73f9fbd411f82dd0d96f0f68b6c
Source dataset
uspto-grants-2008_07
Patent number
US07402674B2

Reaction notes

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