Sodium hydride → HCID 22234982, compound

HRID 749523Notes

Reaction equation

HRID 749523 reaction equation
[Br:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][CH:7]([C:10]#[N:11])[C:8]#[N:9])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:17][CH2:18][C:19]([F:22])([F:21])[F:20]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]([CH2:17][CH2:18][C:19]([F:22])([F:21])[F:20])([C:8]#[N:9])[C:10]#[N:11])=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 11345355HCID 11345355, compound

Product 1

HCID 22234982HCID 22234982, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 3.86 g of (4-bromobenzyl)malononitrile, 25 ml of N,N-dimethylformamide, 0.72 g of sodium hydride (60% in oil), and 3.20 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 4.61 g of 2-(4-bromobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (9)).

Sources & evidence

ORD record
ord-682037c25b974bc6a93c585903ce2ce3
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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