Sodium hydride → HCID 22235076, compound

HRID 749545Notes

Reaction equation

HRID 749545 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]Br.[H-].[Na+].[F:13][C:14]([F:23])([F:22])[CH2:15][CH2:16][CH:17]([C:20]#[N:21])[C:18]#[N:19]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][C:17]([CH2:16][CH2:15][C:14]([F:13])([F:22])[F:23])([C:18]#[N:19])[C:20]#[N:21]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 40672073-Methoxybenzyl bromideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22235076HCID 22235076, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.20 g of 3-methoxybenzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-tri-fluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.09 g of 2-(3-methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (32)).

Sources & evidence

ORD record
ord-0e34edbab23c45bf9258c5dfa915d070
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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