Sodium hydride → HCID 22234998, compound

HRID 749552Notes

Reaction equation

HRID 749552 reaction equation
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]Br.[H-].[Na+].[F:15][C:16]([F:25])([F:24])[CH2:17][CH2:18][CH:19]([C:22]#[N:23])[C:20]#[N:21]>CN(C)C=O>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][C:19]([CH2:18][CH2:17][C:16]([F:15])([F:24])[F:25])([C:20]#[N:21])[C:22]#[N:23]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 107281972,3-Dimethoxybenzyl bromideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22234998HCID 22234998, compoundYield 83.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.23 g of 2,3-dimethoxybenzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.26 g of 2-(2,3-dimethoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (40)).

Sources & evidence

ORD record
ord-3d00179df67c4dbcb19b412a8eba2033
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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