Sodium hydride → HCID 86593469, compound

HRID 749566Notes

Reaction equation

HRID 749566 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH:11]([C:14]#[N:15])[C:12]#[N:13])[CH3:10])=[CH:5][CH:4]=1.[H-].[Na+].Br[CH2:21][CH2:22][C:23]([F:26])([F:25])[F:24]>CN(C)C=O>[F:1][C:2]([F:16])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([CH:9]([C:11]([CH2:21][CH2:22][C:23]([F:26])([F:25])[F:24])([C:14]#[N:15])[C:12]#[N:13])[CH3:10])=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 22235056HCID 22235056, compound

Product 1

HCID 86593469HCID 86593469, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.48 g of 2-(1-(4-(trifluoromethyl)phenyl)ethyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.34 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.26 g of 2-(1-(4-(trifluoromethyl)phenyl)ethyl-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (57)).

Sources & evidence

ORD record
ord-e63629aaffa04bb5870d3a30408e8faa
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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