1-Bromo-2-Chloroethane → HCID 22234972, compound

HRID 749571Notes

Reaction equation

HRID 749571 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH2:5][CH:6]([C:9]#[N:10])[C:7]#[N:8].C(=O)([O-])[O-].[K+].[K+].Br[CH2:21][CH2:22][Cl:23]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH2:5][C:6]([CH2:21][CH2:22][Cl:23])([C:7]#[N:8])[C:9]#[N:10]

Participants

5

Reactant 3

HCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium CarbonateHCID 22235008HCID 22235008, compound

Product 1

HCID 22234972HCID 22234972, compoundYield 44.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 1.01 g of (3-chlorobenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 1.38 g of potassium carbonate, and 1.44 g of 1-bromo-2-chloroethane, and according to the process described in the Production Example 1, there was obtained 0.60 g of 2-(3-chlorobenzyl)-2-(2-chloroethyl)malononitrile (the present compound (63)).

Sources & evidence

ORD record
ord-4291a7d5ffcb482da1ea76692088aa9f
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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