2-Fluoroethyl bromide → HCID 22234984, compound

HRID 749577Notes

Reaction equation

HRID 749577 reaction equation
[Br:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].[H-].[Na+].Br[CH2:17][CH2:18][F:19]>CN(C)C=O>[Br:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH2:4][C:5]([CH2:17][CH2:18][F:19])([C:6]#[N:7])[C:8]#[N:9]

Participants

5

Reactant 3

HCID 129822-Fluoroethyl bromideHCID 24758Sodium hydrideHCID 22235074HCID 22235074, compound

Product 1

HCID 22234984HCID 22234984, compoundYield 41.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.24 g of (2-bromobenzyl)malononitrile, 3 ml of N,N-dimethylformamide, 0.10 g of sodium hydride (60% in oil), and 0.13 g of 1-bromo-2-fluoroethane, and according to the process described in the Production Example 1, there was obtained 0.12 g of 2-(2-bromobenzyl)-2-(2-fluoroethyl)malononitrile (the present compound (69)).

Sources & evidence

ORD record
ord-813693015fb5465d91e860b2146b9ad3
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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