Sodium hydride → HCID 22235042, compound

HRID 749579Notes

Reaction equation

HRID 749579 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:10])[CH:9]=1)[CH2:5]Br.[H-].[Na+].[F:13][C:14]([F:23])([F:22])[CH2:15][CH2:16][CH:17]([C:20]#[N:21])[C:18]#[N:19]>CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:10])[CH:9]=1)[CH2:5][C:17]([CH2:16][CH2:15][C:14]([F:13])([F:22])[F:23])([C:18]#[N:19])[C:20]#[N:21]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 5188963,5-Difluorobenzyl bromideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22235042HCID 22235042, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.21 g of 3,5-difluorobenzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.21 g of 2-(3,5-difluorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (71)).

Sources & evidence

ORD record
ord-92f3c21c72cb48d4922a187e8d812124
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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