Sodium hydride → HCID 22235057, compound

HRID 749583Notes

Reaction equation

HRID 749583 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[H-].[Na+].[F:12][C:13]([F:22])([F:21])[CH2:14][CH2:15][CH:16]([C:19]#[N:20])[C:17]#[N:18]>CN(C)C=O>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][C:16]([CH2:15][CH2:14][C:13]([F:12])([F:21])[F:22])([C:17]#[N:18])[C:19]#[N:20]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 67968alpha-Bromo-o-fluorotolueneHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22235057HCID 22235057, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.19 g of 2-fluorobenzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.17 g of 2-(2-fluorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (75)).

Sources & evidence

ORD record
ord-51be30785dc44b1f821479e48abd9f4f
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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