alpha-Bromo-o-chlorotoluene → HCID 22235023, compound

HRID 749588Notes

Reaction equation

HRID 749588 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[H-].[Na+].[F:12][C:13]([F:22])([F:21])[CH2:14][CH2:15][CH:16]([C:19]#[N:20])[C:17]#[N:18]>CN(C)C=O>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][C:16]([CH2:15][CH2:14][C:13]([F:12])([F:21])[F:22])([C:17]#[N:18])[C:19]#[N:20]

Participants

5

Reactant 3

HCID 11905alpha-Bromo-o-chlorotolueneHCID 24758Sodium hydrideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22235023HCID 22235023, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 0.21 g of 2-chlorobenzyl bromide, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.22 g of 2-(2-chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (81)).

Sources & evidence

ORD record
ord-52b6f7cb7b5f49b29097b96ede8a9c51
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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