反应详情

A solution of azide, 50d, (0.25 g; 0.89 mmol) in 20 mL of ethyl acetate was hydrogenated with Degussa palladium (20 mole %) under 1 atmosphere of hydrogen overnight. The reaction mixture was filtered over celite and the celite was eluted with 2×10 mL of EtOAc. The filtrate was concentrated in vacuo to afford 230 mg of an oil that was used directly for the next step without further purification.

1. filtrationThe reaction mixture was filtered over celite
2. washthe celite was eluted with 2×10 mL of EtOAc
3. concentrationThe filtrate was concentrated in vacuo