Potassium Carbonate → HCID 59752954, compound

HRID 750098Notes

Reaction equation

HRID 750098 reaction equation
[C:1]1([C:7]2[CH:11]=[CH:10][NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+]>C(C(C)=O)C>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][N:9]2[CH:10]=[CH:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:8]2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 699934-Methyloxybenzyl chlorideHCID 178420101HCID 178420101, compound

Product 1

HCID 59752954HCID 59752954, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 3-phenyl-1H-pyrazole (1.35 g, 9.36 mmol), 4-methoxybenzyl chloride (1.5 g, 9.7 mmol) and K2CO3 (3.3 g, 24.2 mmol) in methyl ethyl ketone was refluxed for 24 h. The salts were filtered off, and the solvent was removed in vacuo. The residue was purified by a column chromatography on silica gel to yield the title compound (2.2 g, 89%).

Workup

  1. temperaturewas refluxed for 24 h
  2. filtrationThe salts were filtered off
  3. customthe solvent was removed in vacuo
  4. customThe residue was purified by a column chromatography on silica gel

Sources & evidence

ORD record
ord-abfe223b0e704837ae0864d230308a05
Source dataset
uspto-grants-2008_07
Patent number
US07402684B2

Reaction notes

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