反应详情

温度

70 °C

[Step 1] To an aqueous solution (180 ml) of sodium sulfite (9.7 g) and sodium hydrogen carbonate (11.8 g) was added 4-cyanobenzenesulfonyl chloride (14.1 g) at room temperature and the mixture was stirred at 70° C. for 4 hrs. The solvent was evaporated under reduced pressure and the obtained residue was purified by medium pressure preparative liquid chromatography (MCI GEL, CHP20P (75-150μ), eluant=water) to give sodium 4-cyanobenzenesulfinate (15.9 g, 99%).

1. customThe solvent was evaporated under reduced pressure
2. customthe obtained residue was purified by medium pressure preparative liquid chromatography (MCI GEL, CHP20P (75-150μ), eluant=water)