2-Methoxybenzaldehyde → HCID 59753866, compound

HRID 750477Notes

Reaction equation

Br[C:2]1[C:3]([Cl:9])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH3:10][O:11][C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH:14]=[O:15]>>[Cl:8][C:5]1[N:4]=[C:3]([Cl:9])[C:2]([CH:14]([C:13]2[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=2[O:11][CH3:10])[OH:15])=[CH:7][N:6]=1

Participants

Reactant 2

HCID 86582-Methoxybenzaldehyde

HCID 2899735-Bromo-2,4-dichloropyrimidine

Product 1

HCID 59753866HCID 59753866, compoundYield 77%

Procedure

The compound was prepared from 5-bromo-2,4-dichloropyrimidine (Aldrich) and 2-methoxybenzaldehyde (Aldrich) in 77% yield in an analogous manner as described in Example 1. 1H NMR (300 MHz, CDCl3) δ 8.75 (s,1 H), 7.34 (d.t. 1H, J=2 Hz, 8 Hz), 7.16 (d,d, 1H, J=1.8 Hz, 7.3 Hz ), 6.96 (d, 1H, J=7.3 Hz), 6.95 (d,1H, J=8 Hz), 1H), 3.85 (s, 3H), 3.148 (br. s, 1H).

Sources & evidence

ORD record: ord-e4b77cdd38f54868bfcc8e2a78e866ac
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07405220B2

Reaction notes

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