2,6-Difluorobenzaldehyde → HCID 59753876, compound

HRID 750479Notes

Reaction equation

HRID 750479 reaction equation
Br[C:2]1[C:3]([Cl:9])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[F:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:12]=1[CH:13]=[O:14]>>[Cl:8][C:5]1[N:4]=[C:3]([Cl:9])[C:2]([CH:13]([C:12]2[C:11]([F:10])=[CH:18][CH:17]=[CH:16][C:15]=2[F:19])[OH:14])=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 1362842,6-DifluorobenzaldehydeHCID 2899735-Bromo-2,4-dichloropyrimidine

Product 1

HCID 59753876HCID 59753876, compoundYield 88%

Procedure

The compound was prepared from 5-bromo-2,4-dichloropyrimidine (Aldrich) and 2,6-difluorobenzaldehyde (Aldrich) in 88% yield in an analogous manner as described in Example 1. 1H NMR (300 MHz, CDCl3) δ 9.09 (s, 1H), 7.35 (m, 1H, 7.92 (m, 2H), 6.35 (s, 1H), 2.67 (br. s, 1H).

Sources & evidence

ORD record
ord-ea278d0d532946d399bf4e075fbb1fbe
Source dataset
uspto-grants-2008_07
Patent number
US07405220B2

Reaction notes

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