Methyl Bromide → HCID 86590082, compound

HRID 750552Notes

Reaction equation

HRID 750552 reaction equation
[C@@:1]12([OH:10])[N:8]([CH3:9])[C@@H:5]([CH2:6][CH2:7]1)[CH2:4][CH:3]=[CH:2]2.[F:11][CH:12]([F:30])[C:13]1([C:27]([OH:29])=[O:28])[C:26]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[O:20][C:19]2[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=2.CBr>C(#N)C>[C@@:1]12([OH:10])[N:8]([CH3:9])[C@@H:5]([CH2:6][CH2:7]1)[CH2:4][CH:3]=[CH:2]2.[F:30][CH:12]([F:11])[C:13]1([C:27]([O-:29])=[O:28])[C:26]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[O:20][C:19]2[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=2

Participants

4

Reactant 2

HCID 6323Methyl BromideHCID 86590083HCID 86590083, compound

Product 1

HCID 86590082HCID 86590082, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

0.6 g (0.002 mol) 4f are taken up in 20 mL acetonitrile and reacted with 1.14 g (0.006 mol) of 50% methyl bromide solution in acetonitrile analogously to step 1.3. Yield: 0.44 g beige crystals (45% of theoretical yield); melting point: 227° C.-228° C.; elemental analysis: calculated: C (58.55), H (4.91), N (2.84); found: C (57.19), H (5.11), N (2.86).

Sources & evidence

ORD record
ord-f192ff41bb8c4c45b9fb5cadd57cee8d
Source dataset
uspto-grants-2008_07
Patent number
US07405224B2

Reaction notes

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