反应详情

To a round bottom flask fitted with a magnetic stir bar and rubber septum was added 2 mL DMF, 6-[2,4-dichlorophenyl]-5-[4-chlorophenyl]-2,4-bis(methylsulfonyl)pyrimidine (Reference Example 5) (98 mg, 0.2 mmol) and potassium cyanide (15 mg, 0.22 mmol). The mixture was heated for 30 min at 80°. By LC, all starting material was consumed (Rt=3.59 min) and a new peak appeared (Rt=3.50 min). The molecular weight corresponded not to the cyano derivative, but to 2-methylsulfonyl-4-hydroxy-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine. (HPLC/MS: m/e=430 (M+)) probably due to the fact that the solvent was not anhydrous.

1. customTo a round bottom flask fitted with a magnetic stir bar
2. temperatureThe mixture was heated for 30 min at 80°
3. customBy LC, all starting material was consumed (Rt=3.59 min)