3-Chlorophenol → HCID 59753891, compound

HRID 750844Notes

Reaction equation

HRID 750844 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[C:8]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[CH:7][N:6]=1)(=O)=O.[Cl:26][C:27]1[CH:28]=[C:29]([OH:33])[CH:30]=[CH:31][CH:32]=1>>[Cl:26][C:27]1[CH:28]=[C:29]([O:33][C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=3[Cl:18])[C:8]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)=[CH:7][N:6]=2)[CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 79333-ChlorophenolHCID 69198607HCID 69198607, compound

Product 1

HCID 59753891HCID 59753891, compound

Procedure

2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine from Reference Example 3 was reacted with 3-chlorophenol according to the procedure described in Example 74 to afford 2-(3-chlorophenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine: HPLC/MS: m/e=461 (M++1); Rt=4.72 min; 1H-NMR 400 MHz (CDCl3): δ 7.00-7.12. (m, 2H), 7.11-7.18 (m, 2H), 7.20-7.30 (m, 7H), 8.60 (s, 1H).

Sources & evidence

ORD record
ord-72ef9bbfc72c40138aae1db19af93817
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

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