Diethylamine → HCID 10437508, compound

HRID 750877Notes

Reaction equation

HRID 750877 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:32]=[CH:33][C:34]=1[F:35])[CH2:5][O:6][C:7]1[N:12]=[C:11](S(C)(=O)=O)[C:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[C:9]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=2[Cl:31])[N:8]=1.[CH2:36]([NH:38][CH2:39][CH3:40])[CH3:37]>>[F:1][C:2]1[CH:3]=[C:4]([CH:32]=[CH:33][C:34]=1[F:35])[CH2:5][O:6][C:7]1[N:12]=[C:11]([N:38]([CH2:39][CH3:40])[CH2:36][CH3:37])[C:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[C:9]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=2[Cl:31])[N:8]=1

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 59753907HCID 59753907, compound

Product 1

HCID 10437508HCID 10437508, compound

Procedure

2-(3,4-Difluorobenzyloxy)-4-(methylsulfonyl)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-pyrimidine (Reference Example 7) (29 mg, 0.05 mmol) was reacted with diethylamine (38.0 mg, 0.52 mmol) by the same general procedure described in Example 103 to afford the title compound: HPLC/MS: m/e=548 (M++1); Rt=3.84 min. 1H-NMR 400 MHz (CDCl3): δ 0.96-1.00 (m, 6H), 3.20-3.30 (m, 4H), 5.30-5.40 (m, 2H), 6.90 (d, J=9 Hz, 1H), 7.01-7.21 (m, 8H), 7.35-7.40 (m, 1H).

Sources & evidence

ORD record
ord-33d35a836ff4403ba9fab462c9ec2fbf
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

Loading…