Sodium Azide → HCID 86591700, compound

HRID 750915Notes

Reaction equation

HRID 750915 reaction equation
[N-:1]=[N+:2]=[N-:3].[Na+].[CH3:5][O:6][C:7]1([O:33][CH3:34])[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:23][C@@H:22]([CH2:24]CS([O-])(=O)=O)[O:21][C:20]3=[O:30])=[CH:15][CH:14]=2)[CH2:9][C:8]1([F:32])[F:31]>CN(C)C=O>[CH3:34][O:33][C:7]1([O:6][CH3:5])[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:23][C@@H:22]([CH2:24][N:1]=[N+:2]=[N-:3])[O:21][C:20]3=[O:30])=[CH:15][CH:14]=2)[CH2:9][C:8]1([F:31])[F:32]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 86591701HCID 86591701, compound

Product 1

HCID 86591700HCID 86591700, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

The mixture of sodium azide (26.0 mmol) and (R)-{3-[4-(4,4-dimethoxy-3,3-difluoropiperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-methanesulfonate (12.0 mmol) in dimethylformamide was heated at 70° C. for 14 hours. The reaction mixture was poured on ice cold water, and the solid was filtered to afford title compound in 88% yield.

Workup

  1. additionThe reaction mixture was poured on ice cold water
  2. filtrationthe solid was filtered

Sources & evidence

ORD record
ord-a00e8298b36c4c34a732dcafc1f10f40
Source dataset
uspto-grants-2008_07
Patent number
US07405228B2

Reaction notes

Loading…