反应详情

To a mixture of 0.31 g of piperidine (3.6 mmol) and 0.47 g of N,N-diisopropylethylamine 3.6 mmol) in 10 mL of dichloromethane was added 0.90 g of 4-iodobenzylbromide (3 mmol). The mixture was allowed to stir for 16 h and partitioned between 50 mL of EtOAc and 50 mL of water. The layers were separated and the EtOAc was washed with 25 mL of brine, dried (MgSO4) and concentrated in vacuo to give 0.90 g of 4-(N-piperidinylmethyl)iodobenzene. The product was used without further purification.

1. custompartitioned between 50 mL of EtOAc and 50 mL of water
2. customThe layers were separated
3. washthe EtOAc was washed with 25 mL of brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo