Tetrabutylammonium Fluoride → ethyl (4-hydroxy-1H-indol-1-yl)acetate

HRID 751192Notes

Reaction equation

HRID 751192 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([O:15][Si](C(C)(C)C)(C)C)[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([OH:15])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 68822793HCID 68822793, compound

Product 1

HCID 68822476ethyl (4-hydroxy-1H-indol-1-yl)acetate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 1 c], [4-(tert-butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid ethyl ester was treated with tetrabutylammonium fluoride in THF to give the title compound as colorless crystals.

Sources & evidence

ORD record
ord-1bd91f1d65a64895801507d8e6695a90
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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