Lithium Hydroxide → {6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynylamino]-indol-1-yl}-acetic acid

HRID 751209Notes

Reaction equation

HRID 751209 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([NH:15][CH2:16][CH2:17][CH2:18][C:19]#[C:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[F:30][C:28]([F:29])([F:31])[O:27][C:24]1[CH:23]=[CH:22][C:21]([C:20]#[C:19][CH2:18][CH2:17][CH2:16][NH:15][C:12]2[CH:13]=[C:14]3[C:9]([CH:8]=[CH:7][N:6]3[CH2:5][C:4]([OH:32])=[O:3])=[CH:10][CH:11]=2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68823310{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynylamino]-indol-1-yl}-acetic acid ethyl ester

Product 1

HCID 11697350{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynylamino]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described for example 1 e], {6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynylamino]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain the title compound as green solid.

Sources & evidence

ORD record
ord-4246f5c6cf174b839e0f050aac8010ef
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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