Azepane → HCID 59754753, compound

HRID 751338Notes

Reaction equation

HRID 751338 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:19]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[N:19]1([C:2]2[N:3]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 8119AzepaneHCID 3147932-chloro-1-phenyl-1H-indole-3-carbaldehyde

Product 1

HCID 59754753HCID 59754753, compoundYield 42%

Procedure

2-Chloro-1-phenyl-1H-indole-3-carboxaldehyde is reacted with azepane as described in Example 2 to give the title compound (42% yield). NMR (CDCl3) 10.25 (1H, s), 8.23 (1H, d), 7.58 (2H, m), 7.51 (1H, m), 7.39 (2H, d), 7.25 (1H, m), 7.15 (1H, t), 6.98 (1H, d), 3.50 (4H, m), 2.55 (4H, m), 2.33 (3H, s), 1.78 (2H, m).

Sources & evidence

ORD record
ord-1742bd4f6b734b12a029a4626a111568
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

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