反应详情

(R)-3-Hydroxypyrrolidine-1-carboxylic acid tert-butyl ester (Sigma-Aldrich) (1.04 g, 5.55 mmol) was methylated and purified in a similar way to Preparation 67 using 60% sodium hydride dispersion (267 mg, 6.68 mmol) and methyl iodide (0.5 mL, 8.06 mmol) in DMF (15 ml). δH (CDCl3): 1.50 (9H, s),1.94–2.02 (2H, m), 3.37 (3H, s), 3.38–3.58 (4H, m), 3.95 (11H, m); Rf0.47 (ethyl acetate/hexane: 1/1).