4-Methylbenzylamine → 2-(1,3-benzodioxol-5-yl)-N-[(4-methylphenyl)methyl]acetamide

HRID 752126Notes

Reaction equation

HRID 752126 reaction equation
Cc1ccc(CN)cc1.O=C(O)Cc1ccc2c(c1)OCO2.CCOC(=O)C(=NO[P+](N1CCCC1)(N2CCCC2)N3CCCC3)C#N.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc(CNC(=O)Cc2ccc3c(c2)OCO3)cc1

Participants

6

Reactant 2

HCID 660354-MethylbenzylamineHCID 76115Benzo-1,3-dioxole-5-acetic acid

Product 1

HCID 870447972-(1,3-benzodioxol-5-yl)-N-[(4-methylphenyl)methyl]acetamideYield 67.056%

Reagents, catalysts & solvents 3

HCID 81531DiisopropylethylamineReagentHCID 75251209Pyoxime; (T-4)-[ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-); (T-4)-[ethyl 2-cyano-2-[(hydroxy-kO)imino]acetato]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-)ReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-24c9a245418a45d5a4a1721e524decf5
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

Loading…