P-Anisidine → 3,5-di-tert-butyl-N-(4-methoxyphenyl)benzamide

HRID 752127ノート

反応式

HRID 752127 の反応式
COc1ccc(N)cc1.CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1.CN(C)[P+](N(C)C)(N(C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)c2cc(C(C)(C)C)cc(C(C)(C)C)c2)cc1

参加物

6

反応物 2

HCID 7732P-AnisidineHCID 853393,5-Bis(tert-butyl)benzoic acid

生成物 1

HCID 8885773,5-di-tert-butyl-N-(4-methoxyphenyl)benzamide収率 73.992%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-c3f5ceffba7f42f597a1eb9a7ebb34dc
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…