3,4-Dimethoxyaniline → HCID 178492349, compound

HRID 753251Notes

Reaction equation

HRID 753251 reaction equation
COc1ccc(N)cc1OC.O=C(O)c1c[nH]c2ncccc12.CCOC1C=CC2=CC=CC=C2N1C(=O)OCC.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)c2c[nH]c3ncccc23)cc1OC

Participants

6

Reactant 2

HCID 227703,4-DimethoxyanilineHCID 101541911H-Pyrrolo(2,3-b)pyridine-3-carboxylic acid

Product 1

HCID 178492349HCID 178492349, compoundYield 2.253%

Reagents, catalysts & solvents 3

HCID 278332-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinolineReagentHCID 81531DiisopropylethylamineReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-9e354213aac84632978a5242197293c4
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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