tert-butyl 5-(1-phenyl-1H-tetrazol-5-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate → HCID 66211639, compound

HRID 75681Notes

Reaction equation

HRID 75681 reaction equation
[C:1]1([N:7]2[C:11]([N:12]3[CH2:16][CH:15]4[CH2:17][N:18](C(OC(C)(C)C)=O)[CH2:19][CH:14]4[CH2:13]3)=[N:10][N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[C:1]1([N:7]2[C:11]([N:12]3[CH2:13][CH:14]4[CH:15]([CH2:17][NH:18][CH2:19]4)[CH2:16]3)=[N:10][N:9]=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 71285583tert-butyl 5-(1-phenyl-1H-tetrazol-5-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Product 1

HCID 66211639HCID 66211639, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

tert-butyl 5-(1-phenyl-1H-tetrazol-5-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (100 mg) was dissolved in 10% TFA solution in CH2Cl2 (10 mL). The reaction was stirred at room temperature for 24 hours. After removal of solvents, the residue, crude 2-(1-phenyl-1H-tetrazol-5-yl)octahydropyrrolo[3,4-c]pyrrole, was used in the further reactions without purification.

Workup

  1. customAfter removal of solvents
  2. customthe residue, crude 2-(1-phenyl-1H-tetrazol-5-yl)octahydropyrrolo[3,4-c]pyrrole, was used in the further reactions without purification

Sources & evidence

ORD record
ord-589d9939fbc34495af7154fbefb39b73
Source dataset
uspto-grants-2014_09
Patent number
US08835454B2

Reaction notes

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