Methylamine → 7-methoxy-N4-(2-morpholinophenyl)quinazolin-4,6-diamine

HRID 75712Notes

Reaction equation

HRID 75712 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[N:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[N+:26]([O-])=O.CN>>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)=[N:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[NH2:26]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 666089317-methoxy-N-(2-morpholinophenyl)-6-nitroquinazolin-4-amine

Product 1

HCID 666097537-methoxy-N4-(2-morpholinophenyl)quinazolin-4,6-diamineYield 35%

Procedure

The procedure of Example 23 was repeated except for using 7-methoxy-N-(2-morpholinophenyl)-6-nitroquinazolin-4-amine instead of 7-methoxy-6-nitroquinazolin-4-yl)methylamine in <Step 7> to obtain the title compound (65 mg, 35%).

Sources & evidence

ORD record
ord-1f1d8061b7934b6bbb47a3d0e1b661e6
Source dataset
uspto-grants-2014_09
Patent number
US08835458B2

Reaction notes

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