反应详情

Methyl 2-(3-(4-(3-(2,4-difluorophenyl) ureido)phenyl)-1,2,4-oxadiazole-5-carboxamido)-3-methylbutanoate was added to THF and to this 1N lithium hydroxide was added and stirred at room temperature. After completion of the reaction the solvent was evaporated and the crude product so obtained was dissolved in ethyl acetate and washed with water, brine, dried by sodium sulphate and concentrated to give a solid. The solid was then purified by column chromatography. Yield 81.89%; 1H NMR (DMSO-d6) δ: 0.96 (d, 6H, C(CH3)2), 2.20 (m, 1H, CHMe2), 4.231 (m, 1H, NHCH), 7.07 (m, 1H), 7.35 (m, 1H), 7.67 (d, 2H), 8.011 (d, 2H), 8.10 (m, 1H), 8.61 (s, 1H, NH), 9.372 (s, 1H, NH), 9.39 (s, 1H, NH), 13.025 (s, 1H, COOH); MS (m/z) 458 (M+−1).

1. additionwas added
2. customAfter completion of the reaction the solvent
3. customwas evaporated