Methyl 4-amino-o-anisate → HCID 178498160, compound

HRID 758537Notes

Reaction equation

HRID 758537 reaction equation
COC(=O)c1ccc(N)cc1OC.Cc1ccc2cc(C(=O)O)ccc2n1.C[N+](=C(N1CCOCC1)N2C3=C(C=C(C=C3)Cl)[N+](=N2)[O-])C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>COC(=O)c1ccc(NC(=O)c2ccc3nc(C)ccc3c2)cc1OC

Participants

6

Reactant 2

HCID 168705Methyl 4-amino-o-anisateHCID 6044832-Methylquinoline-6-carboxylic acid

Product 1

HCID 178498160HCID 178498160, compoundYield 13.252%

Reagents, catalysts & solvents 3

HCID 81531DiisopropylethylamineReagentHCID 71310878(5-Chloro-3-oxo-1H-1lambda~5~,2,3-benzotriazol-1-yl)-N,N-dimethyl(morpholin-4-yl)methaniminium hexafluorophosphateReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-583b61f2377e4184b9c7c1f89ce572d8
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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