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HRID75855

反应详情

EQUATION

反应方程式

HRID 75855 的结构方程式

REACTANTS

反应物

1
结构：CCOC(=O)c1csc(-c2ccc([N+](=O)[O-])cc2)n1
HCID3742475

Ethyl 2-(4-nitrophenyl)-1,3-thiazole-4-carboxylate

C12H10N2O4S

PRODUCTS

生成物

1
结构：O=C(O)c1csc(-c2ccc([N+](=O)[O-])cc2)n1
HCID1473825

2-(4-nitrophenyl)-1,3-thiazole-4-carboxylic Acid

C10H6N2O4S

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Li+].[OH-]
溶剂HCID3939

Lithium hydroxide anhydrous

HLiO

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

To a solution of Ethyl 2-(4-nitrophenyl)thiazole-4-carboxylate in THF, 1N LiOH was added at RT and stirred for 2-3 hr. After completion of reaction THF was removed under reduced pressure. Obtained material was dissolved in water acidified with 1N HCl and white solid precipitated out. It was filtered and dried. Yield 4.4 gm (97%). MS (ESI) m/z: 249(M−H)−; 1HNMR (DMSO-d6, 300 MHz): δ 13.233 (s, 1H), 8.658 (s, 1H), 8.358 (d, 2H), 8.269 (d, 2H).

WORKUP

后处理

  1. customwas removed under reduced pressure
  2. dissolutionObtained material was dissolved in water
  3. customprecipitated out
  4. filtrationIt was filtered
  5. customdried