反应详情

温度

180 °C

An autoclave is charged with 25.0 g (128 mmol) 4-bromobenzylcyanide, 190 mL dimethylcarbonate and 0.900 g (6.51 mmol) K2CO3 and stirred for 16 h at 180° C. Then the reaction mixture is allowed to cool to r.t., the mixture is diluted with EtOAc and washed with water (1×), aq. 10% Na2S2O3 solution (1×) and brine (1×). The organic layer is dried with MgSO4 and the solvent is removed in vacuo. The residue is purified by destillation (bath temperature 204° C., head temperature 153° C.).

1. temperatureto cool to r.t.
2. washwashed with water (1×), aq. 10% Na2S2O3 solution (1×) and brine (1×)
3. dry with materialThe organic layer is dried with MgSO4
4. customthe solvent is removed in vacuo
5. customThe residue is purified by destillation (bath temperature 204° C., head temperature 153° C.)