反应详情

温度

90 °C

5.95 g (21.7 mmol) 1-(4-iodophenyl)-butane-2-one (I39) are added to 150 mL 2-propanol and transferred into an autoclav. 25.1 g (326 mmol) NH4OAc and 4.09 g (65.1 mmol) NaCNBH3 are added and the mixture is stirred at 90° C. over night. The reaction is quenched by the addition of sat. aq. NaHCO3 solution and extracted with EtOAc (3×). The combined organic layers are washed with brine, dried with Na2SO4 and the solvent is removed in vacuo. The compound is used without further purification.

1. customThe reaction is quenched by the addition of sat. aq. NaHCO3 solution
2. extractionextracted with EtOAc (3×)
3. washThe combined organic layers are washed with brine
4. dry with materialdried with Na2SO4
5. customthe solvent is removed in vacuo
6. customThe compound is used without further purification